Celiac disease is an immune-mediated disease with a strong genetic component. The majority of patients with celiac disease are HLA-DQ2- or DQ8-positive. Twin studies have nevertheless shown that environmental factors also influence the development of disease. The role of infection, particularly gastroenteritis, in modifying disease risk was nevertheless unclear.

Dr. John Murray, a Mayo Clinic gastroenterologist who specializes in celiac disease, presents a brief overview of the pathophysiology, diagnosis, and management of the disease. Dr. Murray begins the video by illustrating the diversity of patients who can be affected by celiac disease. This includes people of “all shapes and sizes [and] all ages.” He [...]